Localized Calcium Signaling and the Control of Coupling at Cx36 Gap Junctions
نویسندگان
چکیده
منابع مشابه
Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice.
Gap junctional intercellular communication between β-cells is crucial for proper insulin biosynthesis and secretion. The aim of this work was to investigate the expression of connexin (Cx)36 at the protein level as well as the function and structure of gap junctions (GJ) made by this protein in the endocrine pancreas of prediabetic mice. C57BL/6 mice were fed a high-fat (HF) or regular chow die...
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Calcium signaling in C6 glioma cells in culture was examined with digital fluorescence video microscopy. C6 cells express low levels of the gap junction protein connexin43 and have correspondingly weak gap junctional communication as evidenced by dye coupling (Naus, C. C. G., J. F. Bechberger, S. Caveney, and J. X. Wilson. 1991. Neurosci. Lett. 126:33-36). Transfection of C6 cells with the cDNA...
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15 صفحه اولUpregulation of Connexins 30 and 32 Gap Junctions in Rat Hippocampus at Transcription Level by Chronic Central Injection of Lipopolysaccharide
Background: Gap junctions composed of connexins (Cx) are functional in cell defense by propagation of toxic/death molecules to neighboring cells. Hippocampus, one of the brain regions with particular vulnerability to damage, has a wide network of gap junctions. Functional response of astrocytic Cx30 and neuronal Cx32 to hippocampal damage is unknown. Methods: We infused lipopolysaccharide (LPS)...
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ژورنال
عنوان ژورنال: eneuro
سال: 2020
ISSN: 2373-2822
DOI: 10.1523/eneuro.0445-19.2020